Warwick bookshop-owning couple's campaign for internet retailer Amazon to pay more corporation tax will be discussed in the House of Commons later.
Frances and Keith Smith handed a petition in to Downing Street in April, which was signed by 170,000 people.
The pair, who have shops in Kenilworth and Warwick, fear for the future of high streets.
Their MP Chris White will lead the debate on multinational companies and UK corporation tax.
Mrs Smith, who set up her first shop in 2004, said she hoped the debate would spark changes within HM Revenue and Customs (HMRC).
"It's the future of the high street we're concerned about," she said.
"It's not just bookshops and it's not just Amazon.
"I want the HMRC to be bolstered so it's up to these companies to prove that they don't have to pay tax."
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